Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with Plasmodium berghei ANKA and Trichinella zimbabwensis-A laboratory animal model for malaria and tissue-dwelling nematodes co-infection
Identifieur interne : 000193 ( Main/Exploration ); précédent : 000192; suivant : 000194Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with Plasmodium berghei ANKA and Trichinella zimbabwensis-A laboratory animal model for malaria and tissue-dwelling nematodes co-infection
Auteurs : Pretty Murambiwa [Afrique du Sud] ; Ekuyikeno Silas [Afrique du Sud] ; Yanga Mdleleni [Afrique du Sud] ; Samson Mukaratirwa [Afrique du Sud, Saint-Christophe-et-Niévès]Source :
- Heliyon [ 2405-8440 ] ; 2020.
Abstract
Malaria remains a major cause of mortality and morbidity in sub-Saharan Africa (SSA) and tissue-dwelling helminth parasites (TDHPs) are also prevalent in this region presenting a geographical overlap in endemicity. There is paucity of information on the specific host immune responses elicited at different phases of the life cycle by the co-infecting helminth parasites. This study aimed at using a laboratory animal model to determine selected chemokine, cytokine and hematological profiles in Sprague-Dawley rats co-infected with
Url:
DOI: 10.1016/j.heliyon.2020.e03475
PubMed: 32140591
PubMed Central: 7044667
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with <italic>Plasmodium berghei</italic> ANKA and <italic>Trichinella zimbabwensis</italic>-A laboratory animal model for malaria and tissue-dwelling nematodes co-infection</title><author><name sortKey="Murambiwa, Pretty" sort="Murambiwa, Pretty" uniqKey="Murambiwa P" first="Pretty" last="Murambiwa">Pretty Murambiwa</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Silas, Ekuyikeno" sort="Silas, Ekuyikeno" uniqKey="Silas E" first="Ekuyikeno" last="Silas">Ekuyikeno Silas</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Mdleleni, Yanga" sort="Mdleleni, Yanga" uniqKey="Mdleleni Y" first="Yanga" last="Mdleleni">Yanga Mdleleni</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Mukaratirwa, Samson" sort="Mukaratirwa, Samson" uniqKey="Mukaratirwa S" first="Samson" last="Mukaratirwa">Samson Mukaratirwa</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis</nlm:aff><country xml:lang="fr">Saint-Christophe-et-Niévès</country><wicri:regionArea>One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine, Basseterre</wicri:regionArea><wicri:noRegion>Basseterre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32140591</idno><idno type="pmc">7044667</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044667</idno><idno type="RBID">PMC:7044667</idno><idno type="doi">10.1016/j.heliyon.2020.e03475</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000586</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000586</idno><idno type="wicri:Area/Pmc/Curation">000586</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000586</idno><idno type="wicri:Area/Pmc/Checkpoint">000177</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000177</idno><idno type="wicri:Area/Ncbi/Merge">001001</idno><idno type="wicri:Area/Ncbi/Curation">001001</idno><idno type="wicri:Area/Ncbi/Checkpoint">001001</idno><idno type="wicri:Area/Main/Merge">000193</idno><idno type="wicri:Area/Main/Curation">000193</idno><idno type="wicri:Area/Main/Exploration">000193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with <italic>Plasmodium berghei</italic> ANKA and <italic>Trichinella zimbabwensis</italic>-A laboratory animal model for malaria and tissue-dwelling nematodes co-infection</title><author><name sortKey="Murambiwa, Pretty" sort="Murambiwa, Pretty" uniqKey="Murambiwa P" first="Pretty" last="Murambiwa">Pretty Murambiwa</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Silas, Ekuyikeno" sort="Silas, Ekuyikeno" uniqKey="Silas E" first="Ekuyikeno" last="Silas">Ekuyikeno Silas</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Mdleleni, Yanga" sort="Mdleleni, Yanga" uniqKey="Mdleleni Y" first="Yanga" last="Mdleleni">Yanga Mdleleni</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Mukaratirwa, Samson" sort="Mukaratirwa, Samson" uniqKey="Mukaratirwa S" first="Samson" last="Mukaratirwa">Samson Mukaratirwa</name><affiliation wicri:level="1"><nlm:aff id="aff1">School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis</nlm:aff><country xml:lang="fr">Saint-Christophe-et-Niévès</country><wicri:regionArea>One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine, Basseterre</wicri:regionArea><wicri:noRegion>Basseterre</wicri:noRegion></affiliation></author></analytic><series><title level="j">Heliyon</title><idno type="eISSN">2405-8440</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malaria remains a major cause of mortality and morbidity in sub-Saharan Africa (SSA) and tissue-dwelling helminth parasites (TDHPs) are also prevalent in this region presenting a geographical overlap in endemicity. There is paucity of information on the specific host immune responses elicited at different phases of the life cycle by the co-infecting helminth parasites. This study aimed at using a laboratory animal model to determine selected chemokine, cytokine and hematological profiles in Sprague-Dawley rats co-infected with <italic>Plasmodium berghei</italic> ANKA (Pb) and a tissue-dwelling nematode, <italic>Trichinella zimbabwensis</italic> (Tz). One-hundred-and-sixty-eight male Sprague-Dawley rats (90–150g) were randomly divided into four experimental groups; Control (n = 42), Pb-infected (n = 42), Tz-infected (n = 42) and Pb <italic>+</italic> Tz-infected group (n = 42). <italic>Trichinella zimbabwensis</italic> infection (3 muscle larvae/g body weight <italic>per os</italic>) was done on day 0 while intra-peritoneal Pb infection (10<sup>5</sup> parasitised RBCs) was done at day 28 of the 42-day experimental study for the co-infection group which corresponded with day 0 of the Pb group on the protocol. Haematological parameters, cytokines (TNF-α, IL-10, IL-4, IL-6), chemokines (CXCL10, CCL5, CCL11) and burden of Tz adult worms and muscle larvae burden were determined as per need for each group. Results showed that Tz infection predisposed the co-infected animals towards rapid development of Pb parasitaemia during co-infection, reaching a higher peak percentage parasitaemia at day 7 post-infection than the Pb mono-infected group at day 6 post-infection. Animals in the co-infected group also exhibited severe anaemia, basophilia, neutrophilia, eosinophilia and lymphopenia at day 7 post Pb infection compared to the control groups. Significant elevation of Pb parasitaemia coincided with elevated pro-inflammatory cytokine TNF-α (<italic>P <</italic> 0.001), regulatory anti-inflammatory IL-10 (<italic>P <</italic> 0.001), and pro-inflammatory chemokines CXCL10 (<italic>P <</italic> 0.001) concentration in comparison to control group, at day 7 post Pb infection. Our results confirm that co-infection of Pb with Tz resulted in increased Pb parasitaemia compared to the control group in the early stages of infection and this might translate to severe malaria.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abanyie, F" uniqKey="Abanyie F">F. Abanyie</name></author><author><name sortKey="Mccracken, C" uniqKey="Mccracken C">C. Mccracken</name></author><author><name sortKey="Kirwan, P" uniqKey="Kirwan P">P. Kirwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abay, S" uniqKey="Abay S">S. Abay</name></author><author><name sortKey="Tilahun, M" uniqKey="Tilahun M">M. Tilahun</name></author><author><name sortKey="Fikrie, N" uniqKey="Fikrie N">N. Fikrie</name></author><author><name sortKey="Habtewold, A" uniqKey="Habtewold A">A. Habtewold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adedoja, A" uniqKey="Adedoja A">A. Adedoja</name></author><author><name sortKey="Tijani, B" uniqKey="Tijani B">B. Tijani</name></author><author><name sortKey="A, A" uniqKey="A A">A. A.</name></author><author><name sortKey="Ojurongbe, T" uniqKey="Ojurongbe T">T. Ojurongbe</name></author><author><name sortKey="Adeyeba, O" uniqKey="Adeyeba O">O. Adeyeba</name></author><author><name sortKey="Ojurongbe, O" uniqKey="Ojurongbe O">O. Ojurongbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ademola, I" uniqKey="Ademola I">I. Ademola</name></author><author><name sortKey="Odeniran, P" uniqKey="Odeniran P">P. Odeniran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anchang Kimbi, J" uniqKey="Anchang Kimbi J">J. Anchang-Kimbi</name></author><author><name sortKey="Elad, D" uniqKey="Elad D">D. Elad</name></author><author><name sortKey="Sotoing, G" uniqKey="Sotoing G">G. Sotoing</name></author><author><name sortKey="Achidi, E" uniqKey="Achidi E">E. Achidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Appay, V" uniqKey="Appay V">V. Appay</name></author><author><name sortKey="Rowland Jones, S" uniqKey="Rowland Jones S">S. Rowland-Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ateba Ngoa, U" uniqKey="Ateba Ngoa U">U. Ateba-Ngoa</name></author><author><name sortKey="Adegnika, A" uniqKey="Adegnika A">A. Adegnika</name></author><author><name sortKey="Zinsou, J" uniqKey="Zinsou J">J. ZInsou</name></author><author><name sortKey="Kassa, R K" uniqKey="Kassa R">R.K. Kassa</name></author><author><name sortKey="Smits, H" uniqKey="Smits H">H. Smits</name></author><author><name sortKey="Massinga Loembe, M" uniqKey="Massinga Loembe M">M. Massinga-Loembe</name></author><author><name sortKey="Mordmuller, B" uniqKey="Mordmuller B">B. Mordmüller</name></author><author><name sortKey="Kremsner, P" uniqKey="Kremsner P">P. Kremsner</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M. Yazdanbakhsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ateba Ngoa, U" uniqKey="Ateba Ngoa U">U. Ateba-ngoa</name></author><author><name sortKey="Zinsou, J" uniqKey="Zinsou J">J. Zinsou</name></author><author><name sortKey="Kassa, R" uniqKey="Kassa R">R. Kassa</name></author><author><name sortKey="Feugap, E" uniqKey="Feugap E">E. Feugap</name></author><author><name sortKey="Honkpehedji, Y" uniqKey="Honkpehedji Y">Y. Honkpehedji</name></author><author><name sortKey="Massinga Loembe, M" uniqKey="Massinga Loembe M">M. Massinga-Loembe</name></author><author><name sortKey="Moundounga, H" uniqKey="Moundounga H">H. Moundounga</name></author><author><name sortKey="Mouima, A" uniqKey="Mouima A">A. Mouima</name></author><author><name sortKey="Mbenkep, L" uniqKey="Mbenkep L">L. Mbenkep</name></author><author><name sortKey="Wammes, L" uniqKey="Wammes L">L. Wammes</name></author><author><name sortKey="Mbow, M" uniqKey="Mbow M">M. Mbow</name></author><author><name sortKey="Kruize, Y" uniqKey="Kruize Y">Y. Kruize</name></author><author><name sortKey="Mombo Ngoma, G" uniqKey="Mombo Ngoma G">G. Mombo-Ngoma</name></author><author><name sortKey="Hounkpatin, A" uniqKey="Hounkpatin A">A. Hounkpatin</name></author><author><name sortKey="Agobe, J" uniqKey="Agobe J">J. Agobe</name></author><author><name sortKey="Saadou, I" uniqKey="Saadou I">I. Saadou</name></author><author><name sortKey="Lell, B" uniqKey="Lell B">B. Lell</name></author><author><name sortKey="Smits, H" uniqKey="Smits H">H. Smits</name></author><author><name sortKey="Kremsner, P" uniqKey="Kremsner P">P. Kremsner</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M. Yazdanbakhsh</name></author><author><name sortKey="Adegnika, A" uniqKey="Adegnika A">A. Adegnika</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baggiolini, A" uniqKey="Baggiolini A">A. Baggiolini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beiting, D" uniqKey="Beiting D">D. Beiting</name></author><author><name sortKey="Gagliardo, L" uniqKey="Gagliardo L">L. Gagliardo</name></author><author><name sortKey="Hesse, M" uniqKey="Hesse M">M. Hesse</name></author><author><name sortKey="Bliss, S" uniqKey="Bliss S">S. Bliss</name></author><author><name sortKey="Meskill, D" uniqKey="Meskill D">D. Meskill</name></author><author><name sortKey="Appleton, J" uniqKey="Appleton J">J. Appleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bostrom, E" uniqKey="Bostrom E">E. Bostrom</name></author><author><name sortKey="Kindstedt, E" uniqKey="Kindstedt E">E. Kindstedt</name></author><author><name sortKey="Silnuite, R" uniqKey="Silnuite R">R. Silnuite</name></author><author><name sortKey="Palmqvist, P" uniqKey="Palmqvist P">P. Palmqvist</name></author><author><name sortKey="Majster, M" uniqKey="Majster M">M. Majster</name></author><author><name sortKey="Holm, C" uniqKey="Holm C">C. Holm</name></author><author><name sortKey="Zwicker, S" uniqKey="Zwicker S">S. Zwicker</name></author><author><name sortKey="Clark, R" uniqKey="Clark R">R. Clark</name></author><author><name sortKey="Onell, S" uniqKey="Onell S">S. Onell</name></author><author><name sortKey="Johansson, I" uniqKey="Johansson I">I. Johansson</name></author><author><name sortKey="Lerner, U" uniqKey="Lerner U">U. Lerner</name></author><author><name sortKey="Lunderg, P" uniqKey="Lunderg P">P. Lunderg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briand, V" uniqKey="Briand V">V. Briand</name></author><author><name sortKey="Watier, L" uniqKey="Watier L">L. Watier</name></author><author><name sortKey="Leh, J" uniqKey="Leh J">J. Leh</name></author><author><name sortKey="Garcia, A" uniqKey="Garcia A">A. Garcia</name></author><author><name sortKey="Cot, M" uniqKey="Cot M">M. Cot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruschi, F" uniqKey="Bruschi F">F. Bruschi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruschi, F" uniqKey="Bruschi F">F. Bruschi</name></author><author><name sortKey="Chiumiento, L" uniqKey="Chiumiento L">L. Chiumiento</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruschi, F" uniqKey="Bruschi F">F. Bruschi</name></author><author><name sortKey="Korenaga, M" uniqKey="Korenaga M">M. Korenaga</name></author><author><name sortKey="Watanabe, N" uniqKey="Watanabe N">N. Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conti, P" uniqKey="Conti P">P. Conti</name></author><author><name sortKey="Digioacchino, M" uniqKey="Digioacchino M">M. Digioacchino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degarege, A" uniqKey="Degarege A">A. Degarege</name></author><author><name sortKey="Animut, A" uniqKey="Animut A">A. Animut</name></author><author><name sortKey="Legesse, M" uniqKey="Legesse M">M. Legesse</name></author><author><name sortKey="Erko, B" uniqKey="Erko B">B. Erko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degarege, A" uniqKey="Degarege A">A. Degarege</name></author><author><name sortKey="Animut, A" uniqKey="Animut A">A. Animut</name></author><author><name sortKey="Legesse, M" uniqKey="Legesse M">M. Legesse</name></author><author><name sortKey="Erko, B" uniqKey="Erko B">B. Erko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degarege, A" uniqKey="Degarege A">A. Degarege</name></author><author><name sortKey="Veledar, E" uniqKey="Veledar E">E. Veledar</name></author><author><name sortKey="Degarege, D" uniqKey="Degarege D">D. Degarege</name></author><author><name sortKey="Erkob" uniqKey="Erkob">Erkob</name></author><author><name sortKey="Nacher, M" uniqKey="Nacher M">M. Nacher</name></author><author><name sortKey="Madhivanan, P" uniqKey="Madhivanan P">P. Madhivanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dixon, H" uniqKey="Dixon H">H. Dixon</name></author><author><name sortKey="Blanchard, C" uniqKey="Blanchard C">C. Blanchard</name></author><author><name sortKey="Deschoolmeester, M" uniqKey="Deschoolmeester M">M. Deschoolmeester</name></author><author><name sortKey="Yuill, N" uniqKey="Yuill N">N. Yuill</name></author><author><name sortKey="Christie, J" uniqKey="Christie J">J. Christie</name></author><author><name sortKey="Rothenberg, M" uniqKey="Rothenberg M">M. Rothenberg</name></author><author><name sortKey="Else, K" uniqKey="Else K">K. Else</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fabre, M" uniqKey="Fabre M">M. Fabre</name></author><author><name sortKey="Beiting, D" uniqKey="Beiting D">D. Beiting</name></author><author><name sortKey="Bliss, S" uniqKey="Bliss S">S. Bliss</name></author><author><name sortKey="Appleton, J" uniqKey="Appleton J">J. Appleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geissmann, F" uniqKey="Geissmann F">F. Geissmann</name></author><author><name sortKey="Manz, M" uniqKey="Manz M">M. Manz</name></author><author><name sortKey="Jung, S" uniqKey="Jung S">S. Jung</name></author><author><name sortKey="Sieweke, M" uniqKey="Sieweke M">M. Sieweke</name></author><author><name sortKey="Merad, M" uniqKey="Merad M">M. Merad</name></author><author><name sortKey="Ley, K" uniqKey="Ley K">K. Ley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Getie, S" uniqKey="Getie S">S. Getie</name></author><author><name sortKey="Wondimeneh, Y" uniqKey="Wondimeneh Y">Y. Wondimeneh</name></author><author><name sortKey="Getnet, G" uniqKey="Getnet G">G. Getnet</name></author><author><name sortKey="Workineh, M" uniqKey="Workineh M">M. Workineh</name></author><author><name sortKey="Worku, L" uniqKey="Worku L">L. Worku</name></author><author><name sortKey="Kassu, A" uniqKey="Kassu A">A. Kassu</name></author><author><name sortKey="Moges, B" uniqKey="Moges B">B. Moges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartgers, F" uniqKey="Hartgers F">F. Hartgers</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M. Yazdanbakhsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, P" uniqKey="Hotez P">P. Hotez</name></author><author><name sortKey="Kamath, A" uniqKey="Kamath A">A. Kamath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, S" uniqKey="Hu S">S. Hu</name></author><author><name sortKey="Korner, H" uniqKey="Korner H">H. Korner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapel, C" uniqKey="Kapel C">C. Kapel</name></author><author><name sortKey="Gamble, H" uniqKey="Gamble H">H. Gamble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinung I, S" uniqKey="Kinung I S">S. Kinung’Hi</name></author><author><name sortKey="Magnussen, P" uniqKey="Magnussen P">P. Magnussen</name></author><author><name sortKey="Kaatano, G M" uniqKey="Kaatano G">G.M. Kaatano</name></author><author><name sortKey="Kishamawe, C" uniqKey="Kishamawe C">C. Kishamawe</name></author><author><name sortKey="Vennervald, B" uniqKey="Vennervald B">B. Vennervald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Legesse, M" uniqKey="Legesse M">M. Legesse</name></author><author><name sortKey="Erko, B" uniqKey="Erko B">B. Erko</name></author><author><name sortKey="Balcha, F" uniqKey="Balcha F">F. Balcha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemaitre, M" uniqKey="Lemaitre M">M. Lemaitre</name></author><author><name sortKey="Watier, L" uniqKey="Watier L">L. Watier</name></author><author><name sortKey="Briand, V" uniqKey="Briand V">V. Briand</name></author><author><name sortKey="Garcia, A" uniqKey="Garcia A">A. Garcia</name></author><author><name sortKey="Hesran, J" uniqKey="Hesran J">J. Hesran</name></author><author><name sortKey="Cot, M" uniqKey="Cot M">M. Cot</name></author><author><name sortKey="Al, E" uniqKey="Al E">E. AL</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyke, K" uniqKey="Lyke K">K. Lyke</name></author><author><name sortKey="Dabo, A" uniqKey="Dabo A">A. Dabo</name></author><author><name sortKey="Arama, C" uniqKey="Arama C">C. Arama</name></author><author><name sortKey="Daou, M" uniqKey="Daou M">M. Daou</name></author><author><name sortKey="Diarra, I" uniqKey="Diarra I">I. Diarra</name></author><author><name sortKey="Wang, A" uniqKey="Wang A">A. Wang</name></author><author><name sortKey="Plowe, C" uniqKey="Plowe C">C. Plowe</name></author><author><name sortKey="Doumbo, O" uniqKey="Doumbo O">O. Doumbo</name></author><author><name sortKey="Sztein, M" uniqKey="Sztein M">M. Sztein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, S" uniqKey="Matthews S">S. Matthews</name></author><author><name sortKey="Tregoning, J" uniqKey="Tregoning J">J. Tregoning</name></author><author><name sortKey="Coyle, A" uniqKey="Coyle A">A. Coyle</name></author><author><name sortKey="Hussell, T" uniqKey="Hussell T">T. Hussell</name></author><author><name sortKey="Openshaw, P" uniqKey="Openshaw P">P. Openshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mboera, L" uniqKey="Mboera L">L. Mboera</name></author><author><name sortKey="Senkoro, K" uniqKey="Senkoro K">K. Senkoro</name></author><author><name sortKey="Rumisha, S" uniqKey="Rumisha S">S. Rumisha</name></author><author><name sortKey="Mayala, B" uniqKey="Mayala B">B. Mayala</name></author><author><name sortKey="Shayo, E" uniqKey="Shayo E">E. Shayo</name></author><author><name sortKey="Mlozi, M" uniqKey="Mlozi M">M. Mlozi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author><author><name sortKey="Gcanga, L" uniqKey="Gcanga L">L. Gcanga</name></author><author><name sortKey="Kamau, J" uniqKey="Kamau J">J. Kamau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author><author><name sortKey="Grange, L L" uniqKey="Grange L">L.L. Grange</name></author><author><name sortKey="Pfukenyi, D" uniqKey="Pfukenyi D">D. Pfukenyi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author><author><name sortKey="Nkulungo, E" uniqKey="Nkulungo E">E. Nkulungo</name></author><author><name sortKey="Matenga, E" uniqKey="Matenga E">E. Matenga</name></author><author><name sortKey="Bhebhe, E" uniqKey="Bhebhe E">E. Bhebhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulu, A" uniqKey="Mulu A">A. Mulu</name></author><author><name sortKey="Legesse, M" uniqKey="Legesse M">M. Legesse</name></author><author><name sortKey="Erko, B" uniqKey="Erko B">B. Erko</name></author><author><name sortKey="Belyhun, Y" uniqKey="Belyhun Y">Y. Belyhun</name></author><author><name sortKey="Nugussie, D" uniqKey="Nugussie D">D. Nugussie</name></author><author><name sortKey="Shimelis, T" uniqKey="Shimelis T">T. Shimelis</name></author><author><name sortKey="Al, E" uniqKey="Al E">E. Al</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mwangi, T" uniqKey="Mwangi T">T. Mwangi</name></author><author><name sortKey="Bethony, J" uniqKey="Bethony J">J. Bethony</name></author><author><name sortKey="Brooker, S" uniqKey="Brooker S">S. Brooker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nacher, M" uniqKey="Nacher M">M. Nacher</name></author><author><name sortKey="Singhasivanon, P" uniqKey="Singhasivanon P">P. Singhasivanon</name></author><author><name sortKey="Yimsamran, S" uniqKey="Yimsamran S">S. Yimsamran</name></author><author><name sortKey="Manibunyong, W" uniqKey="Manibunyong W">W. Manibunyong</name></author><author><name sortKey="Thanyavanich, N" uniqKey="Thanyavanich N">N. Thanyavanich</name></author><author><name sortKey="Wuthisen, R" uniqKey="Wuthisen R">R. Wuthisen</name></author><author><name sortKey="Looareesuwan, S" uniqKey="Looareesuwan S">S. Looareesuwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noone, C" uniqKey="Noone C">C. Noone</name></author><author><name sortKey="Parkinson, M" uniqKey="Parkinson M">M. Parkinson</name></author><author><name sortKey="Dowling, D" uniqKey="Dowling D">D. Dowling</name></author><author><name sortKey="Aldridge, A" uniqKey="Aldridge A">A. Aldridge</name></author><author><name sortKey="Kirwan, P" uniqKey="Kirwan P">P. Kirwan</name></author><author><name sortKey="Molloy, S" uniqKey="Molloy S">S. Molloy</name></author><author><name sortKey="Asaolu, S" uniqKey="Asaolu S">S. Asaolu</name></author><author><name sortKey="Holland, C" uniqKey="Holland C">C. Holland</name></author><author><name sortKey="O Neill, S" uniqKey="O Neill S">S. O'Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onkoba, N" uniqKey="Onkoba N">N. Onkoba</name></author><author><name sortKey="Chimbari, M" uniqKey="Chimbari M">M. Chimbari</name></author><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onkoba, W" uniqKey="Onkoba W">W. Onkoba</name></author><author><name sortKey="Chimbari, M" uniqKey="Chimbari M">M. Chimbari</name></author><author><name sortKey="Kamau, J" uniqKey="Kamau J">J. Kamau</name></author><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onkoba, W" uniqKey="Onkoba W">W. Onkoba</name></author><author><name sortKey="Kamau, J" uniqKey="Kamau J">J. Kamau</name></author><author><name sortKey="Chimbari, M" uniqKey="Chimbari M">M. Chimbari</name></author><author><name sortKey="Mukaratirwa, S" uniqKey="Mukaratirwa S">S. Mukaratirwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picherot, M" uniqKey="Picherot M">M. Picherot</name></author><author><name sortKey="Oswald, I" uniqKey="Oswald I">I. Oswald</name></author><author><name sortKey="Cote, M" uniqKey="Cote M">M. Cote</name></author><author><name sortKey="Noeckler, K" uniqKey="Noeckler K">K. Noeckler</name></author><author><name sortKey="Guerhier, F L" uniqKey="Guerhier F">F.L. Guerhier</name></author><author><name sortKey="Boireau, P" uniqKey="Boireau P">P. Boireau</name></author><author><name sortKey="Valle E, I" uniqKey="Valle E I">I. Valle´E</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sangweme, D" uniqKey="Sangweme D">D. Sangweme</name></author><author><name sortKey="Midzi, N" uniqKey="Midzi N">N. Midzi</name></author><author><name sortKey="Zinyowera Mutapuri, S" uniqKey="Zinyowera Mutapuri S">S. Zinyowera-Mutapuri</name></author><author><name sortKey="Mduluza, T" uniqKey="Mduluza T">T. Mduluza</name></author><author><name sortKey="Diener West, M" uniqKey="Diener West M">M. Diener-West</name></author><author><name sortKey="Kumar, N" uniqKey="Kumar N">N. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapiro, A" uniqKey="Shapiro A">A. Shapiro</name></author><author><name sortKey="Tukahebwa, E" uniqKey="Tukahebwa E">E. Tukahebwa</name></author><author><name sortKey="Kasten, J" uniqKey="Kasten J">J. Kasten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, C" uniqKey="Shi C">C. Shi</name></author><author><name sortKey="Pamer, E" uniqKey="Pamer E">E. Pamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sokhna, C" uniqKey="Sokhna C">C. Sokhna</name></author><author><name sortKey="Hesran, J L" uniqKey="Hesran J">J.L. Hesran</name></author><author><name sortKey="Mbaye, P" uniqKey="Mbaye P">P. Mbaye</name></author><author><name sortKey="Akiana, J" uniqKey="Akiana J">J. Akiana</name></author><author><name sortKey="Camara, P" uniqKey="Camara P">P. Camara</name></author><author><name sortKey="Diop, M" uniqKey="Diop M">M. Diop</name></author><author><name sortKey="Ly, A" uniqKey="Ly A">A. Ly</name></author><author><name sortKey="Druilhe, P" uniqKey="Druilhe P">P. Druilhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tacke, F" uniqKey="Tacke F">F. Tacke</name></author><author><name sortKey="Randolph, G" uniqKey="Randolph G">G. Randolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Bogaart, E" uniqKey="Van Den Bogaart E">E. Van-Den-Bogaart</name></author><author><name sortKey="Talha, A" uniqKey="Talha A">A. Talha</name></author><author><name sortKey="Straetemans, M" uniqKey="Straetemans M">M. Straetemans</name></author><author><name sortKey="Mens, P" uniqKey="Mens P">P. Mens</name></author><author><name sortKey="Adams, E" uniqKey="Adams E">E. Adams</name></author><author><name sortKey="Grobusch, M" uniqKey="Grobusch M">M. Grobusch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wakelin, D" uniqKey="Wakelin D">D. Wakelin</name></author><author><name sortKey="Goyal, P" uniqKey="Goyal P">P. Goyal</name></author><author><name sortKey="Dehlawi, M" uniqKey="Dehlawi M">M. Dehlawi</name></author><author><name sortKey="Hermanek, J" uniqKey="Hermanek J">J. Hermanek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yona, S" uniqKey="Yona S">S. Yona</name></author><author><name sortKey="Kim, K" uniqKey="Kim K">K. Kim</name></author><author><name sortKey="Wolf, Y" uniqKey="Wolf Y">Y. Wolf</name></author><author><name sortKey="Milder, A" uniqKey="Milder A">A. Milder</name></author><author><name sortKey="Varol, D" uniqKey="Varol D">D. Varol</name></author><author><name sortKey="Breker, M" uniqKey="Breker M">M. Breker</name></author><author><name sortKey="Strauss Ayali, D" uniqKey="Strauss Ayali D">D. Strauss-Ayali</name></author><author><name sortKey="Viukov, S" uniqKey="Viukov S">S. Viukov</name></author><author><name sortKey="Guilliams, M" uniqKey="Guilliams M">M. Guilliams</name></author><author><name sortKey="Misharin, A" uniqKey="Misharin A">A. Misharin</name></author><author><name sortKey="Hume, D" uniqKey="Hume D">D. Hume</name></author><author><name sortKey="Perlman, H" uniqKey="Perlman H">H. Perlman</name></author><author><name sortKey="Malissen, B" uniqKey="Malissen B">B. Malissen</name></author><author><name sortKey="Zelzer, E" uniqKey="Zelzer E">E. Zelzer</name></author><author><name sortKey="Jung, S" uniqKey="Jung S">S. Jung</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Saint-Christophe-et-Niévès</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Murambiwa, Pretty" sort="Murambiwa, Pretty" uniqKey="Murambiwa P" first="Pretty" last="Murambiwa">Pretty Murambiwa</name></noRegion><name sortKey="Mdleleni, Yanga" sort="Mdleleni, Yanga" uniqKey="Mdleleni Y" first="Yanga" last="Mdleleni">Yanga Mdleleni</name><name sortKey="Mukaratirwa, Samson" sort="Mukaratirwa, Samson" uniqKey="Mukaratirwa S" first="Samson" last="Mukaratirwa">Samson Mukaratirwa</name><name sortKey="Silas, Ekuyikeno" sort="Silas, Ekuyikeno" uniqKey="Silas E" first="Ekuyikeno" last="Silas">Ekuyikeno Silas</name></country><country name="Saint-Christophe-et-Niévès"><noRegion><name sortKey="Mukaratirwa, Samson" sort="Mukaratirwa, Samson" uniqKey="Mukaratirwa S" first="Samson" last="Mukaratirwa">Samson Mukaratirwa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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